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The matricellular protein sparc

Splet15. feb. 2013 · Among other characteristics, matricellular proteins modulate cellular processes by binding to cell surface receptors and initiating intracellular signal transduction. The most well characterized matricellular proteins are SPARC (secreted protein acidic and rich in cysteine), tenascin cytotactin (tenascin C) and thrombospondin … Splet10. jul. 2002 · The matrix in wounds contains anti-adhesive proteins, often members of a group of proteins known as matricellular proteins, which may facilitate partial cell detachment and hence permit cell...

Tumour-derived SPARC drives vascular permeability and ... - Nature

Splet25. nov. 2016 · Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for the regulation of cell growth … Splet01. jun. 2016 · Secreted protein acidic and rich in cysteine (SPARC) is a collagen-binding matricellular protein highly expressed during fibrosis. Fibrosis is a prominent component of cardiac aging that reduces myocardial elasticity. Previously, we reported that SPARC deletion attenuated myocardial stiffness and collagen deposition in aged mice. mnt for gastric bypass https://thebankbcn.com

SPARCL1 - Wikipedia

SpletThe matricellular protein SPARC (also known as osteonectin and BM-40) is expressed abundantly in lens epithelium. That SPARC-null mice exhibit early cataractogenesis, indicates a role for... SpletSPARC+/+ (top row) and SPARC−/− (bottom row) mice were injected in the skin with 107 CFU of attenuated S. typhimurium SL3261 AT. ... We studied the function of the … Splet15. jan. 2013 · Matricellular proteins have been classified as a family of non-structural matrix proteins capable of modulating a variety of biological processes within the … mnt for hepatic encephalopathy

Matricellular protein SPARC is translocated to the nuclei of ...

Category:SPARC, a matricellular protein: at the crossroads of cell-matrix.

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The matricellular protein sparc

Matricellular Protein - an overview ScienceDirect Topics

Splet12. avg. 2024 · 总的来说，SPARC是一种CR模拟脂肪因子，是炎症和干扰素反应的免疫代谢检查点，可用于延缓与年龄相关的代谢和功能衰退。 据介绍，热量限制 (CR)诱导的免疫 … Splet11. dec. 2015 · Methods. We collected tracheal aspirates and MSCs from mechanically-ventilated premature infants during the first week of life. Tracheal aspirate and MSC-conditioned media were analyzed for seven matricellular proteins including SPARC (for Secreted Protein, Acidic, Rich in Cysteine, also called osteonectin) and normalized to …

The matricellular protein sparc

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Splet01. dec. 2000 · SPARC is a multifunctional glycoprotein that belongs to the matricellular group of proteins. It modulates cellular interaction with the extracellular matrix (ECM) by … Splet13. sep. 2024 · Matricellular proteins are widely and dynamically expressed non-structural proteins that influence extracellular matrix structure and participate in cell-cell communication. Increased SPARC expression is associated with obesity, diabetes, coronary artery disease, and chronic infection ( Kos and Wilding, 2010 ).

Splet19. okt. 2016 · The SPARC (secreted protein acidic and rich in cysteine) protein is matricellular molecule regulating interactions between cells and their surrounding extracellular matrix (ECM). This protein thus governs fundamental cellular functions such as cell adhesion, proliferation and differentiation. Splet15. feb. 2013 · Among other characteristics, matricellular proteins modulate cellular processes by binding to cell surface receptors and initiating intracellular signal …

SpletSPARC is a matricellular protein that governs extracellular matrix (ECM) deposition and maturation during tissue remodeling, particularly, during … Splet07. okt. 2009 · SPARC (secreted protein acidic and rich in cysteine), also known as osteonectin and BM-40, is a multifunctional secreted glycoprotein that exemplifies the matricellular class of proteins (Framson and Sage 2004 ).

Splet152-291: 9.88e-63: EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC); SPARC, also termed basement-membrane protein 40 (BM-40), or osteonectin (ON), is a prototypic collagen-binding matricellular protein that is essential for embryo development in invertebrates and highly expressed in …

Splet01. nov. 2003 · It is hypothesized that TGF-β2 upregulates SPARC expression in human TM through Smad-dependent (Smad2/3) or -independent (p38) signaling pathways, and SPARC may be a downstream regulatory node of TGF -β2-mediated IOP elevation. Expand 34 PDF View 1 excerpt, cites background Save Alert mntfreeias loginSplet17. avg. 2024 · 2024年8月12日，耶鲁大学的研究人员在 Cell 子刊 Immunity 上发表了题为： The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging 的研究论文。 该研究表明，适度的热量限制能够减少一种衰老相关蛋白 SPARC ... mnt for hypothyroidismSpletSPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC. It interacts with the extracellular matrix to create intermediate states of cell adhesion. Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is … mnt for high cholesterol