Chuan he fto
WebJan 20, 2024 · that mediate oxidative demethylation of m6A. FTO has been demon-strated to demethylate m 6A on mRNA, m A m on mRNA and snRNAs, and m1A on tRNA (Mauer et al, 2024, 2024; Wei et al, ... The EMBO Journal P Cody He & Chuan He. system development and function, spermatogenesis, and skeletal function (Lin et al, 2024; Yoon … http://he-group.uchicago.edu/
Chuan he fto
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WebMay 11, 2024 · Chuan He. The University of Chicago, HHMI/Chemistry, Biochemistry and Molecular Biology. Abstract: Over 100 types of post-transcriptional RNA modifications … WebJun 4, 2024 · FTO knockdown with siRNA led to increased amounts of m(6)A in mRNA, whereas overexpression of FTO resulted in decreased amounts of m(6)A in human cells. We further show the partial colocalization of FTO with nuclear speckles, which supports the notion that m(6)A in nuclear RNA is a major physiological substrate of FTO.
WebJul 27, 2024 · In tests, researchers found that by adding a gene that encodes for a protein called FTO both rice and potato plants increased yields by 50%. ... University of Chicago professor Chuan He was one of the leaders of the research team. He’s research focuses on how genes are expressed and ways to regulate those processes. It used to be thought … WebJan 10, 2013 · The discovery of FTO as an RNA demethylase raises questions regarding how general such a process could be and whether m 6 A plays roles in other biological processes. We present here ALKBH5 as another mammalian RNA demethylase that catalyzes the removal of the m 6 A modification on nuclear RNA (mostly mRNA) in vitro …
WebApr 30, 2013 · FTO, which was identified in several genome-wide-association studies to be associated with obesity and type II diabetes 10, 11, 12, is a member of the non-haem Fe II /α-ketoglutarate... WebMar 25, 2014 · α-ketoglutarate-dependent dioxygenases FTO and ALKBH5 are m 6 A demethylases of mRNA (and other types of nuclear RNA) that affect biological processes such as development, energy homeostasis and...
WebNov 19, 2024 · The “eraser” proteins FTO and ALKBH5 remove the m 6 A modification (Jia et al., 2011; Zheng et al., 2013). ... Chuan He ([email protected]). Materials Availability. Antibodies targeting the Ser43 phosphorylation of METTL3 were generated in collaboration with Lifetein LLC. There are restrictions to the availability of the anti-Ser43 ...
Welcome to the He Group! Prof. Chuan He was selected as one of the winners of the 2024 Wolf Prize in Chemistry. UChicago News. Wolf Foundation . Exon architecture controls mRNA m 6 A suppression and gene expression Science 2024, 379, 677-682/ RNA's joints play key role in our gene expression, UChicago scientists find UChicago News crystal mcilroyWebJul 1, 2024 · In 2024, Chuan He’s group employed a dCas13b-FTO editor to demethylate the m 6A of LINE1, resulting in an increased half lifetime of LINE1 and globally increased chromatin accessibility. In terms of physiological relevance, targeting LINE1 by dCas13b-FTO resulted in decreased differentiation capacity and increased cell renewal in mouse … crystal mcgriff dallas txWebOct 17, 2011 · image: Professor Chuan He has led researchers who have identified a dynamic new cellular pathway, represented here in molecular form, in the genetic … dwt vaccine advisoryWebChuan He N6-methyladenosine (m6A) is the most abundant mRNA modification and plays crucial roles in diverse physiological processes. Utilizing a Massively Parallel Assay for m6A (MPm6A), we... dw tv a fondoWebNov 30, 2024 · Recently, He and collaborators added a gene encoding for a protein called FTO –a gene that erases chemical marks on RNA–to rice plants. The experiment increased the plants’ mass by 50% and produced 50% more rice. The plants also grew longer root systems, which help plants be more drought tolerant. dw tv directWebJul 1, 2024 · In 2011, we discovered the first RNA demethylase, FTO, a protein belonging to the AlkB family iron- and 2-ketoglutarate (2-KG)-dependent dioxygenases and which is associated with human fat mass obesity. ... Sigrid; He, Chuan (2024) The emerging biology of RNA post-transcriptional modifications. RNA Biol 14:156-163 Zhao, Boxuan Simen; … crystal mcguireWebJul 22, 2024 · He and Guifang Jia, a former UChicago postdoctoral researcher who is now an associate professor at Peking University, began to wonder how it affected plant … crystal mckee facebook