WebMar 30, 2024 · CHOP can inhibit the expression of the molecular chaperone glucose-regulated protein 78 (GRP78)/immunoglobulin heavy chain-binding protein (BiP) and the anti-apoptotic gene B-cell lymphoma-2 (BCL-2), deplete glutathione (GSH) increase the ER-derived reactive oxygen species (ROS), and cause apoptosis [3, 7]. WebMar 3, 2024 · Ferroptosis, a form of regulated cell death, is characterized by an excessive degree of iron accumulation and lipid peroxidation.
Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer
WebFeb 23, 2024 · Ferroptosis is a new form of programmed cell death characterized by lipid-reactive oxygen species (ROS). 14 Reactive species play a critical role in cellular signalling and physiology. WebJan 10, 2024 · Ferroptosis is involved in cerebral I/R injury, but the mechanism remains unclear. Prostaglandin E2 (PGE2) is potential to regulate ferroptosis. This study mainly … thorium mimics
Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk …
WebFerroptosis-related genes associated with overall survival in the training set were then extracted, and the least absolute shrinkage and selection operator Cox regression model was used to establish an eight-gene signature, comprising ZEB1, PSAT1, NGB, NFE2L2, LAMP2, HIF1A, FH, and CXCL2. Results: The signature exhibited significant … WebApr 5, 2024 · Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a critical modulator of the fatty acid metabolic pathway. SCD1 expression is associated with poor prognosis in several cancer types. SCD1 triggers an iron-dependent cell death called ferroptosis and elevated levels ... WebJul 1, 2024 · ATF4 also induces the expression of CAAT/enhancer binding protein (C/EBP) homologous protein (CHOP), which is involved in cell death induction [75], [76]. ... Ferroptosis, which is a recently recognized form of programmed cell death characterized by the accumulation of lipid peroxidation through ROS generation via the Fenton reaction ... thorium metal ampoule